Genome-wide analysis identifies gallstone-susceptibility loci including genes regulating gastrointestinal motility.
Cameron J FairfieldThomas M DrakeRiinu PiusAndrew D BretherickArchie CampbellDavid W ClarkJonathan Andrew FallowfieldCaroline HaywardNeil Cowan HendersonAndrii IakovlievPeter K JoshiNicholas L MillsDavid J PorteousPrakash RamachandranRobert K SempleCatherine A ShawCathie L W SudlowPaul R H J TimmersJames F WilsonStephen J WigmoreAthina SpiliopoulouEwen M HarrisonPublished in: Hepatology (Baltimore, Md.) (2021)
This GWAS demonstrates the polygenic nature of gallstone risk and identifies 46 novel susceptibility loci. We implicate genes influencing gastrointestinal motility in the pathogenesis of gallstones.