Ag-Catalyzed ring-opening of tertiary cycloalkanols for C-H functionalization of cyclic aldimines.
Jingjing WangXue LiuZiyan WuFeng LiMing-Liang ZhangYiman MiJunhao WeiYao ZhouLan-Tao LiuPublished in: Chemical communications (Cambridge, England) (2021)
We firstly describe a silver-catalyzed direct C-H functionalization of cyclic aldimines with cyclopropanols and cyclobutanols via a radical-mediated C-C bond cleavage strategy. The desired products were generated in decent yields with wide substrate scope under mild reaction conditions. In addition, a gram-scale reaction and synthetic transformation of the product were performed.