PTPRK, an EGFR Phosphatase, Is Decreased in CeD Biopsies and Intestinal Organoids.

Merlin NanayakkaraClaudia BellomoFrancesca FuroneMariantonia MaglioAntonella MaranoGiuliana LaniaMonia PorporaMartina NicolettiSalvatore AuricchioMaria Vittoria Barone

Published in: Cells (2022)

modulation of PTPRK levels can reduce or increase pEGFR, pERK and proliferation in CeD or CTR organoids, respectively. The CeD organoids can be a good model to study the mechanisms of the disease.

Keyphrases

small cell lung cancer
induced pluripotent stem cells
signaling pathway
epidermal growth factor receptor
tyrosine kinase
endoplasmic reticulum stress
endoplasmic reticulum
ultrasound guided
protein kinase