Platelets: the point of interconnection among cancer, inflammation and cardiovascular diseases.
Massimiliano CamilliGiulia IannacconeGiulia La VecchiaLuigi CappannoliRoberto ScacciavillaniGiorgio MinottiMassimo MassettiFilippo CreaNadia AspromontePublished in: Expert review of hematology (2021)
Platelet-cancer crosstalk generates a vicious feed-back loop involving tumor cells and secreting molecules that activate platelets, which in turn promote cancer-associated inflammation, proliferation, spreading and immune system evasion. Therefore, platelets inhibition may represent an innovative therapeutical strategy offered to cancer patients, in the perspective of personalized medicine.