Heme Oxygenase-1 Suppresses Wnt Signaling Pathway in Nonalcoholic Steatohepatitis-Related Liver Fibrosis.

Jinghua DuWeiguang RenQingshan ZhangNa FuFang HanPo CuiWencong LiLingbo KongSuxian ZhaoRongqi WangYu-Guo ZhangLuting YangLi KongYue-Min Nan

Published in: BioMed research international (2020)

Our study demonstrated that HO-1 inhibited the activation of canonical and noncanonical Wnt signaling pathways in NASH-related liver fibrosis. Thus, these results may suggest a new therapeutic strategy for NASH-related liver fibrosis.

Keyphrases

liver fibrosis
signaling pathway
pi k akt
stem cells
cell proliferation
epithelial mesenchymal transition
oxidative stress