CircARCN1 aggravates atherosclerosis by regulating HuR-mediated USP31 mRNA in macrophages.
Zhicheng PanJialan LvLiding ZhaoKaidi XingRunze YeYuesheng ZhangSiyuan ChenPeng YangHailong YuYangkai LinRuobing LiDongfei WangJuan FangYang DongJianpeng ShengXiaolin WangGe ShanShan ZhangHongqiang ChengQingbo XuXiao-Gang GuoPublished in: Cardiovascular research (2024)
Our findings provide solid evidence macrophagic-expressed circARCN1 plays a role in atherosclerosis development by regulating HuR-mediated USP31 mRNA stability and NF-κB activation, suggesting that circARCN1 may serve as a factor for atherosclerotic lesion formation.