Mechanisms of myostatin and activin A accumulation in chronic kidney disease.
Stanislas BatailleLaetitia DouMarc BartoliMarion SalléeJulien AniortBorhane FerkakRania ChermitiNathalie McKayNathalie Da SilvaStéphane BurteyStéphane PoitevinPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022)
During CKD, myostatin and activin A blood concentrations are increased. Myostatin is not overproduced, suggesting only an impaired renal clearance, but activin A is overproduced in the kidney and heart. We propose to add myostatin and activin A to the list of uremic toxins.