Autocrine TNF-α Increases Penetration of Myelin-Associated Glycoprotein Antibodies Across the Blood-Nerve Barrier in Anti-MAG Neuropathy.

Ryota SatoFumitaka ShimizuMotoi KuwaharaYoichi MizukamiKenji WatanabeToshihiko MaedaYasuteru SanoYukio TakeshitaMichiaki KogaSusumu KusunokiTakashi Kanda

Published in: Neurology(R) neuroimmunology & neuroinflammation (2023)

Sera from individuals with anti-MAG neuropathy increased transcellular IgM/anti-MAG antibody permeability via autocrine TNF-α secretion and NF-κB signaling in the BNB.

Keyphrases

rheumatoid arthritis
signaling pathway
oxidative stress
endothelial cells
multiple sclerosis