NRF2 activation with Protandim attenuates salt-induced vascular dysfunction and microvascular rarefaction.

Jessica R C PriestleyKatie E FinkJoe M McCordJulian H Lombard

Published in: Microcirculation (New York, N.Y. : 1994) (2019)

These results suggest that dietary activation of NRF2 protects against salt-induced vascular dysfunction, vascular oxidative stress, and microvascular rarefaction by upregulating antioxidant defenses and reducing mitochondrial ROS levels.

Keyphrases

oxidative stress
diabetic rats
dna damage
ischemia reperfusion injury
induced apoptosis
high glucose
drug induced
cell death
signaling pathway
anti inflammatory
innate immune