Differential newborn DNA methylation among individuals with complex congenital heart defects and childhood lymphoma.

Melissa A RichardWei YangPagna SokMing LiSuzan L CarmichaelJulie von BehrenPeggy ReynoldsPaul G FisherRonnie Thomad CollinsCharlotte A HobbsBarbara LukeGary M Shaw Philip J Lupo

Published in: Birth defects research (2022)

We identified associations between molecular changes present in the genome at birth and risk of childhood lymphoma among those with CHD. Our findings also highlight novel perinatal exposures that may underlie methylation changes in CHD predisposing to lymphoma.

Keyphrases

dna methylation
diffuse large b cell lymphoma
genome wide
gene expression
early life
pregnant women
air pollution
gestational age