A proof-of-concept study on the use of a fluorescein-based 18 F-tracer for pretargeted PET.

Hugo HelbertEmily M PloegDouwe F SamploniusSimon N BlokInes F AntunesVerena I BöhmerGert LuurtsemaRudi A J O DierckxBen L FeringaPhilip H ElsingaWiktor SzymanskiWijnand Helfrich

Published in: EJNMMI radiopharmacy and chemistry (2022)

F-tracer, is presented. It is shown to selectively target EpCAM-expressing cells in vitro and its further evaluation with different bispecific antibodies demonstrates the versatility of the approach.

Keyphrases

positron emission tomography
pet imaging
induced apoptosis
computed tomography
cell cycle arrest
pet ct
circulating tumor cells
cell adhesion
endoplasmic reticulum stress
signaling pathway
cell death
pi k akt