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A proof-of-concept study on the use of a fluorescein-based 18 F-tracer for pretargeted PET.

Hugo HelbertEmily M PloegDouwe F SamploniusSimon N BlokInes F AntunesVerena I BöhmerGert LuurtsemaRudi A J O DierckxBen L FeringaPhilip H ElsingaWiktor SzymanskiWijnand Helfrich
Published in: EJNMMI radiopharmacy and chemistry (2022)
F-tracer, is presented. It is shown to selectively target EpCAM-expressing cells in vitro and its further evaluation with different bispecific antibodies demonstrates the versatility of the approach.
Keyphrases
  • positron emission tomography
  • pet imaging
  • induced apoptosis
  • computed tomography
  • cell cycle arrest
  • pet ct
  • circulating tumor cells
  • cell adhesion
  • endoplasmic reticulum stress
  • signaling pathway
  • cell death
  • pi k akt