A self-healable metallohydrogel for drug encapsulations and drug release.
Mita DuttaShreya BanerjeeMahitosh MandalManish BhattacharjeePublished in: RSC advances (2023)
A self-healable metallohydrogel (MOG) of Mn(ii) has been prepared using a low molecular weight gelator, Na 2 HL {H 3 L = l-(3,5-di- tert -butyl-2-hydroxy-benzyl)amino aspartic acid}. The MOG has been characterized by MALDI TOF mass spectrometry, rheological studies, IR spectroscopy, and microscopic techniques. Non-steroidal anti-inflammatory drug (NSAID), indomethacin (IND) and anti-cancer drug gemcitabine (GEM) were encapsulated into the metallohydrogel. The GEM-loaded metallogel (MOG_GEM) shows better delivery and more adverse cytotoxicity than the drug against breast cancer cell lines MDA-MB-468 and 4T1. The anti-cancer property was evaluated with in vitro MTT cytotoxic assay, live-dead assay and cell migration assay. In vitro cytotoxicity assay against RAW 264.7 cell line with the treatment of MOG_IND shows the improved anti-inflammatory response in the case of MOG_IND compared to the drug alone.
Keyphrases
- mass spectrometry
- high throughput
- inflammatory response
- drug release
- cell migration
- drug delivery
- adverse drug
- high resolution
- emergency department
- drug induced
- liquid chromatography
- radiation therapy
- signaling pathway
- cell death
- lipopolysaccharide induced
- high performance liquid chromatography
- escherichia coli
- single molecule
- staphylococcus aureus
- pi k akt
- ionic liquid
- capillary electrophoresis
- single cell
- case control