The effect of methylethylpiridinol addition to the therapy on the level of pigment epithelium-derived factor and oxidative status in patients with diabetic nephropathy: randomized controlled open-label clinical study.
Sergey Sergeevich PopovElena Igorevna AnufrievaEvgenii Dmitrievich Kryl'skiiKonstantin Konstantinovich ShulginAleksey Nikolaevich VerevkinTatyana Nikolaevna PopovaAleksander Nikolaevich PashkovPublished in: Journal of diabetes and metabolic disorders (2021)
The methylethylpiridinol addition to the therapy had a more potent stimulating effect on the patients' oxidative status in comparison with standard treatment, and reliably decreased pigment epithelium-derived factor level in patients' serum. The observed differences seem to be associated with the antioxidant activity of methylethylpiridinol which contributing to the mitigation of oxidative stress reducing at diabetes mellitus.