Dual Regeneration of Muscle and Nerve by Intramuscular Infusion of Mitochondria in a Nerve Crush Injury Model.

Meei-Ling SheuChiung-Chyi ShenHsi-Kai TsouMeng Yin YangHong-Lin SuJason SheehanMing-Hong ChangHong-Shiu ChenHung-Chuan Pan

Published in: Neurosurgery (2021)

The local infusion of mitochondria can successfully prevent denervated muscle atrophy and augment nerve regeneration by reducing oxidative stress in denervated muscle.

Keyphrases

skeletal muscle
stem cells
oxidative stress
peripheral nerve
low dose
cell death
reactive oxygen species
wound healing
ischemia reperfusion injury
signaling pathway
optical coherence tomography