Supramolecular nanoprodrug based on a chloride channel blocker and glycosylated pillar[5]arenes for targeted chemoresistance cancer therapy.
Ke YangKe MaManman YangYinghua LvYuxin PeiZhichao PeiPublished in: Chemical communications (Cambridge, England) (2023)
A supramolecular nanoprodrug (DOX@GP5⊃Pro-NFA) was constructed based on the host-guest complexation of chloride channel blocker prodrug (Pro-NFA) and glycosylated pillar[5]arene (GP5), which could target tumor cells via galactose and release DOX/NFA responsively under esterase stimulation. In vitro studies revealed that this supramolecular nanoprodrug can overcome drug resistance through inhibiting chloride channels as well as inhibiting the migration of HepG2/ADR cells. This strategy can therefore achieve enhanced potency in chemotherapy through reverse chemoresistance.
Keyphrases
- cancer therapy
- water soluble
- drug delivery
- induced apoptosis
- signaling pathway
- energy transfer
- anti inflammatory
- cell cycle arrest
- angiotensin converting enzyme
- wastewater treatment
- single cell
- angiotensin ii
- adverse drug
- emergency department
- endoplasmic reticulum stress
- squamous cell carcinoma
- locally advanced
- pi k akt
- case control
- drug release
- rectal cancer