Serine deficiency exacerbates psoriatic skin inflammation by regulating S-adenosyl methionine-dependent DNA methylation and NF-κB signaling activation in keratinocytes.

Qinqin MengYing LiuLeiqing YaoZhimiao MaLu GuoTing HuYixin LuoJiaoling ChenErle DangZhengxiao Li

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2023)

Our study revealed the crucial role of PHGDH in antagonizing psoriatic skin inflammation and indicated that targeting serine metabolism may represent a novel therapeutic strategy for treating psoriasis.

Keyphrases

oxidative stress
dna methylation
wound healing
rheumatoid arthritis
ankylosing spondylitis
disease activity
soft tissue
signaling pathway
gene expression
genome wide
lps induced
systemic lupus erythematosus
drug delivery
nuclear factor
immune response
amino acid
copy number