Insights into the in-vitro Susceptibility and Drug-Drug Interaction Profiles Against Drug-Resistant and Susceptible Mycobacterium tuberculosis Clinical Isolates in Amhara, Ethiopia.

Aynias SeidYilak GirmaEseye DerebMeseret KassaSemira NureddinAyenesh AbebeNega Berhane

Published in: Infection and drug resistance (2024)

S315T substitutions were associated with high level of RIF and INH resistance. It is concluded that REDCA can quantitatively determine anti-mycobacterial synergy and that LEV being of potential use against INH-resistant isolates including MDR-TB when combined with RIF+INH and INH+EMB.

Keyphrases

mycobacterium tuberculosis
drug resistant
pulmonary tuberculosis
multidrug resistant
acinetobacter baumannii
adverse drug
emergency department
cystic fibrosis
risk assessment
climate change
pseudomonas aeruginosa