GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors.

Debanjan BhattacharyaRiccardo BarilleDonatien Kamdem ToukamVaibhavkumar S GawaliLaura KallayTaukir AhmedHawley BrownSepideh RezvanianAniruddha KarvePankaj B DesaiMario MedvedovicKyle WangDan IonascuNusrat HarunChenran WangAndrew M BaschnagelJoshua A KritzerJames M CookDaniel A Pomeranz KrummelSoma Sengupta

Published in: bioRxiv : the preprint server for biology (2023)

. GABA(A) receptor activation increases survival of mice bearing lung metastatic brain tumors.A selective-autophagic response is stimulated by GABA(A) receptor activation that includes multimerization of GABARAP and Nix.Employing a new nanomolar affinity peptide that abrogates autophagosome formation inhibits cytotoxicity elicited by GABA(A) receptor activation.

Keyphrases

cell death
squamous cell carcinoma
oxidative stress
signaling pathway
brain injury
cerebral ischemia