Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1.

Juan GaoYun BaoShushu GePeisen SunJiaojiao SunJianmin LiuFeng ChenLi HanZhongyuan CaoJun QinGilbert C WhiteZhen XuYan-Qing Ma

Published in: Cell communication and signaling : CCS (2019)

Taken together, our findings suggest that sharpin may complex with both kindlin-1 and the integrin β1 CT to restrict the talin head domain binding, thus inhibiting β1-integrin activation.

Keyphrases

signaling pathway
cell adhesion
cell migration
computed tomography
image quality
contrast enhanced
dna binding
optic nerve
optical coherence tomography