Systematic Evaluation of Antigenic Stimulation in Chronic Lymphocytic Leukemia: Humoral Immunity as Biomarkers for Disease Evolution.
Alicia Landeira-ViñuelaMiguel AlcocebaAlmudena Navarro-BailónCarlota Arias-HidalgoPablo Juanes-VelascoJose Manuel Sanchez-SantosQuentin Al LecrevisseCarlos Eduardo PedreiraMarina Luque García-VaqueroAngela-Patricia HernándezEnrique MontalvilloRafael GongoraJavier De Las RivasMarcos González-DíazAlberto OrfaoManuel FuentesPublished in: Cancers (2023)
Quantitative differences in immunoglobulin serum levels could be potential biomarkers for disease progression. In the top 5 tumoral antigens, we detected autoantibodies (IgM and IgG) against proteins related to cell homeostasis and metabolism in the studied cohort. The top 5 microbial antigens were associated with respiratory and gastrointestinal infections; moreover, the subsets with better prognostics were characterized by a reactivation of Cytomegalovirus. The viral humoral response could be a potential prognosis biomarker for disease progression.