Potential therapeutic antibodies targeting specific adiponectin isoforms in rheumatoid arthritis.

Yeon-Ah LeeDae-Hyun HahmJung Yeon KimBonjun SurHyun Min LeeChun Jeih RyuHyung-In YangKyoung Soo Kim

Published in: Arthritis research & therapy (2018)

mAbs against human adiponectin isomers can potentially be developed as therapeutic antibodies to target specific detrimental isoforms of adiponectin while maintaining the functions of beneficial isoforms.

Keyphrases

metabolic syndrome
rheumatoid arthritis
insulin resistance
endothelial cells
disease activity
cancer therapy
induced pluripotent stem cells
ankylosing spondylitis
skeletal muscle
idiopathic pulmonary fibrosis