Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice.
Gesine ReichartJohannes MayerCindy ZehmTimo KirschsteinTursonjan TokayFalko LangeSimone BaltruschMarkus TiedgeGeorg FuellenSaleh IbrahimRüdiger KöhlingPublished in: Acta physiologica (Oxford, England) (2018)
Our findings demonstrate that a complex IV mutation leads to mitochondrial dysfunction that translates into survival.