The Role of Zinc in Developed Countries in Pediatric Patients: A 360-Degree View.
Flavia PadoanElena PiccoliAngelo PietrobelliLuis Alberto Moreno AznarGiorgio PiacentiniLuca PecoraroPublished in: Biomolecules (2024)
Zinc is an important trace element for growth and health at pediatric ages. Zinc is fundamental in inflammatory pathways, oxidative balance, and immune function. Zinc exhibits anti-inflammatory properties by modulating Nuclear Factor-kappa (NF-κB) activity and reducing histamine release from basophils, leukocytes, and mast cells. Furthermore, its antioxidant activity protects against oxidative damage and chronic diseases. Finally, zinc improves the ability to trigger effective immune responses against pathogens by contributing to the maturation of lymphocytes, the production of cytokines, and the regulation of apoptosis. Given these properties, zinc can be considered an adjunctive therapy in treating and preventing respiratory, nephrological, and gastrointestinal diseases, both acute and chronic. This review aims to deepen the role and metabolism of zinc, focusing on the role of supplementation in developed countries in pediatric diseases.
Keyphrases
- nuclear factor
- oxide nanoparticles
- toll like receptor
- immune response
- oxidative stress
- healthcare
- public health
- signaling pathway
- anti inflammatory
- mental health
- stem cells
- liver failure
- cell death
- intensive care unit
- inflammatory response
- endoplasmic reticulum stress
- dendritic cells
- bone marrow
- hepatitis b virus
- multidrug resistant
- social media
- health information
- cell cycle arrest