Memories of a young student: the early days of splicing regulation with François Gros.
Domenico LibriPublished in: Comptes rendus biologies (2024)
I joined the laboratory of François Gros as a young student in the mid-1980s and worked on the characterization of the β -tropomyosin gene in chicken and the regulation of alternative splicing of its transcript, under the supervision of Marc Fiszman. In particular, I was interested in how secondary structures of the RNA influence the recognition of exons specifically used in muscle cells. I will recall a few memories on how interacting with François on this project shaped my perception of the scientific process and of the relationships between models and data. Later I worked on many aspects of RNA biology, from transcription to mRNP biogenesis and non-coding RNAs.
Keyphrases
- induced apoptosis
- middle aged
- cell cycle arrest
- medical education
- skeletal muscle
- quality improvement
- electronic health record
- genome wide
- medical students
- nucleic acid
- transcription factor
- big data
- endoplasmic reticulum stress
- copy number
- gene expression
- dna methylation
- signaling pathway
- cell death
- machine learning
- oxidative stress
- high school
- artificial intelligence