T Lymphocyte-Derived Exosomes Transport MEK1/2 and ERK1/2 and Induce NOX4-Dependent Oxidative Stress in Cardiac Microvascular Endothelial Cells.
Filip RolskiMarcin CzepielKarolina TkaczKatarzyna FrytMaciej SiedlarGabriela KaniaPrzemysław BłyszczukPublished in: Oxidative medicine and cellular longevity (2022)
T cells in immune response and represent potential important triggers of NOX4-dependent endothelial dysfunction. Neutralization of the prooxidative aspect of CD4-exosomes could open perspectives for the development of new therapeutic strategies in inflammatory cardiovascular diseases.
Keyphrases
- oxidative stress
- immune response
- endothelial cells
- mesenchymal stem cells
- cardiovascular disease
- stem cells
- pi k akt
- signaling pathway
- left ventricular
- cell proliferation
- minimally invasive
- ischemia reperfusion injury
- diabetic rats
- bone marrow
- human health
- cardiovascular risk factors
- coronary artery disease
- vascular endothelial growth factor