Evolving Therapeutic Landscape of Intracerebral Hemorrhage: Emerging Cutting-Edge Advancements in Surgical Robots, Regenerative Medicine, and Neurorehabilitation Techniques.
Danyang ChenZhixian ZhaoShenglun ZhangShiling ChenXuan WuJian ShiNa LiuChao PanYingxin TangCai MengXingwei ZhaoBo TaoWenjie LiuDiansheng ChenHan DingPing ZhangZhouping TangPublished in: Translational stroke research (2024)
Intracerebral hemorrhage (ICH) is the most serious form of stroke and has limited available therapeutic options. As knowledge on ICH rapidly develops, cutting-edge techniques in the fields of surgical robots, regenerative medicine, and neurorehabilitation may revolutionize ICH treatment. However, these new advances still must be translated into clinical practice. In this review, we examined several emerging therapeutic strategies and their major challenges in managing ICH, with a particular focus on innovative therapies involving robot-assisted minimally invasive surgery, stem cell transplantation, in situ neuronal reprogramming, and brain-computer interfaces. Despite the limited expansion of the drug armamentarium for ICH over the past few decades, the judicious selection of more efficacious therapeutic modalities and the exploration of multimodal combination therapies represent opportunities to improve patient prognoses after ICH.
Keyphrases
- stem cell transplantation
- robot assisted
- clinical practice
- brain injury
- high dose
- healthcare
- minimally invasive
- cerebral ischemia
- atrial fibrillation
- white matter
- case report
- low dose
- deep learning
- machine learning
- pain management
- single cell
- subarachnoid hemorrhage
- resting state
- blood brain barrier
- combination therapy
- replacement therapy