Nasal intermittent positive pressure ventilation during less invasive surfactant administration in preterm infants: An open-label randomized controlled study.

Carlo DaniMarcello NapolitanoCiro BaroneAngelo MannaGabriella NigroGianfranco ScarpelliElvira BonannoSara GattoFrancesco CavigioliCarlo ForcelliniEnrico PetoelloRenzo BeghiniMartina CiarciàMonica FuscoFabio MoscaAnna LavizzariEloisa GittoLetteria BarbusciaPasqua BettaCarmine MattiaLuigi CorvagliaStefania VedovatoGiovanni VentoGianfranco MaffeiRaffaele FalsaperlaPaola LagoLuca BoniGianluca Listanull null

Published in: Pediatric pulmonology (2024)

The application of NIPPV or NCPAP during LISA in very preterm infants supported with NCPAP before and after surfactant administration had similar effects on the short-term respiratory outcome and are both safe. Our study does not support the use of NIPPV during LISA.

Keyphrases

preterm infants
low birth weight
open label
double blind
phase iii
placebo controlled
high intensity
clinical trial
mechanical ventilation
respiratory failure
acute respiratory distress syndrome