YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma.

Rui-Chao ChaiYu-Zhou ChangXin ChangBo PangSong Yuan AnKe-Nan ZhangYuan-Hao ChangTao JiangYong-Zhi Wang

Published in: Journal of hematology & oncology (2021)

Our findings confirmed that YTHDF2 promotes the malignant progression of gliomas and revealed important insight into the upstream regulatory mechanism of NF-κB activation via UBXN1 with a primary focus on m6A modification.

Keyphrases

signaling pathway
lps induced
pi k akt
nuclear factor
oxidative stress
high grade
transcription factor
inflammatory response
single cell
toll like receptor