Evaluation of Age-Dependent Immune Signatures in Patients With Multiple Sclerosis.

Melanie EschbornMarc PawlitzkiTimo WirthChristopher NelkeSteffen Pfeuffer Andreas Schulte-MecklenbeckLisa LohmannLeoni RolfesKatrin PapeMaria EveslageStefan BittnerCatharina C GrossTobias RuckHeinz WiendlSven G MeuthLuisa Klotz

Published in: Neurology(R) neuroimmunology & neuroinflammation (2021)

Our data illustrate that aging in MS is associated with a dysbalance between costimulatory and immunoregulatory signals provided by CD8 T cells favoring a proinflammatory phenotype and, more importantly, a pattern of premature immune aging in the CD8 T-cell compartment of young patients with MS with potential implications for disease severity.

Keyphrases

electronic health record
mass spectrometry
multiple sclerosis
ms ms
gene expression
middle aged
deep learning
risk assessment
machine learning
big data