Sex differences in the polygenic architecture of hearing problems in adults.

Flavio De AngelisOana A ZeleznikFrank R WendtGita A PathakDaniel S TyleeAntonella De LilloDora KollerBrenda Cabrera-MendozaRoyce E CliffordAdam X MaihoferCaroline M NievergeltGary C CurhanSharon G CurhanRenato Polimanti

Published in: Genome medicine (2023)

The results provide many novel insights into the biology and epidemiology of HP in adults. Our sex-specific analyses and transcriptomic associations highlighted molecular pathways that may be targeted for drug development or repurposing. Additionally, the potential causal relationships identified may support novel preventive screening programs to identify individuals at risk.

Keyphrases

mental health
public health
single molecule
hearing loss
risk assessment