Long-Term Kinetics of Serum Galactomannan during Treatment of Complicated Invasive Pulmonary Aspergillosis.
Athanasios TragiannidisChristina LinkeCarlos L Correa-MartinezHeidrun HerbrüggenFrieder SchaumburgAndreas H GrollPublished in: Journal of fungi (Basel, Switzerland) (2023)
Several studies have evaluated the serum galactomannan (GM) antigen assay in pediatric patients, and there is convincing evidence for its usefulness as a diagnostic tool for invasive Aspergillus infections in patients with acute leukemias or post allogeneic hematopoietic cell transplantation (HCT). Less is known about the utility of the assay in monitoring responses to treatment in patients with established invasive aspergillosis (IA). Here, we present the long-term kinetics of serum galactomannan in two severely immunocompromised adolescents with invasive pulmonary aspergillosis (IPA) who were cured after complicated clinical courses. We also review the utility of the GM antigen assay in serum as a prognostic tool around the time of diagnosis of IA and as a biomarker to monitor disease activity in patients with established IA and assess responses to systemic antifungal therapy.
Keyphrases
- disease activity
- high throughput
- rheumatoid arthritis
- systemic lupus erythematosus
- pulmonary hypertension
- young adults
- physical activity
- stem cell transplantation
- bone marrow
- stem cells
- low dose
- cell death
- signaling pathway
- single cell
- high dose
- combination therapy
- acute respiratory distress syndrome
- case control
- aqueous solution
- cell therapy
- cell wall