Sanqi Qushi Granule Alleviates Proteinuria and Podocyte Damage in NS Rat: A Network Pharmacology Study and in vivo Experimental Validation.

Lijuan WangHuoliang LiuYi WangXiaoFan HongXiaoyan HuangMiaoru HanDan WangWenjun ShanPing LiHaowen GuBo LiuKun Bao

Published in: Drug design, development and therapy (2023)

By combining network pharmacology with experimental verification in vivo, this work confirmed the treatment efficacy of SQG for NS. SQG protected podocyte from injury and inhibited kidney apoptosis in NS rats via the PI3K/AKT pathway at least partially.

Keyphrases

dengue virus
oxidative stress
zika virus
high glucose
endoplasmic reticulum stress
cell cycle arrest
aedes aegypti
endothelial cells
replacement therapy
signaling pathway