Infiltration of CD3+ and CD8+ lymphocytes in association with inflammation and survival in pancreatic cancer.
Gerik W Tushoski-AlemánKelly M HerremansPatrick W UnderwoodAshwin AkkiAndrea N RinerJose G TrevinoSong HanSteven J HughesPublished in: PloS one (2024)
In this work, we found a marked heterogeneity in infiltrating CD3+ and CD8+ lymphocytes and individual inflammatory responses in PDAC. Future mechanistic studies should explore personalized therapeutic strategies to target the immune and inflammatory components of the tumor microenvironment.