Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
Fredrick R SchumacherStephanie L SchmitShuo JiaoChristopher K EdlundHansong WangBen ZhangLi HsuShu-Chen HuangChristopher P FischerJohn F HarjuGregory E IdosFlavio LejbkowiczFrank J ManionKevin McDonnellCaroline E McNeilMarilena MelasHedy S RennertWei ShiDuncan C ThomasDavid J Van Den BergCarolyn M HutterAaron K AragakiKatja ButterbachBette J CaanChristopher S CarlsonStephen J ChanockKeith R CurtisCharles S FuchsManish GalaEdward L GiovannucciStephanie M GogartenRichard B HayesBrian HendersonDavid J HunterRebecca D JacksonLaurence N KolonelCharles KooperbergSébastien KüryAndrea LaCroixCathy C LaurieCecelia A LaurieMathieu LemireDavid LevineJing MaKaren W MakarConghui QuDarin TavernaCornelia M UlrichKana WuSuminori KonoDee W WestSonja I BerndtStéphane BezieauHermann BrennerPeter T CampbellAndrew T ChanJenny Chang-ClaudeGerhard A CoetzeeDavid V ContiDavid DugganJane C FigueiredoBarbara K FortiniSteven J GallingerW James GaudermanGraham GilesRoger GreenRobert HaileTabitha A HarrisonMichael HoffmeisterJohn L HopperThomas J HudsonEric J JacobsMotoki IwasakiSun Ha JeeMark JenkinsWei-Hua JiaAmit JoshiLi LiNoralene M LindorKeitaro MatsuoVictor MorenoBhramar MukherjeePolly A NewcombJohn D PotterLeon RaskinGad RennertStephanie RosseGianluca SeveriRobert E SchoenDaniela SeminaraXiao-Ou ShuMartha L SlatteryShoichiro TsuganeEmily WhiteYong-Bing XiangBrent W ZankeWei ZhengLoic Le MarchandGraham CaseyStephen B GruberUlrike PetersPublished in: Nature communications (2015)
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.