SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia.

Alejandro Pérez-FernándezGuillermo López-RuanoRodrigo Prieto-BermejoCarla IjurkoMaría Díez-CampeloFermín Sánchez-GuijoÁngel Hernández-Hernández

Published in: Journal of experimental & clinical cancer research : CR (2019)

SHP1 and SHP2 are relevant mediators of differentiation in AML cells and their inhibition either alone or in combination with prostratin seems a promising differentiation-based therapeutic strategy against different subtypes of AML beyond APL.

Keyphrases

acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
induced apoptosis
cell cycle arrest
cell death
anti inflammatory