Compounds 18a, 23b, and 11c are strong lipid peroxidation inhibitors (99%, 78%, and
92%). Compound 28c inhibits SLOX-1 with IC50 =8.5 μM whereas 11a and 22a highly inhibit
COX-2 (IC50 6 and 5 μM Hybrids 14c and 17c inhibit both enzymes. Compound 29c showed the
highest anti-inflammatory activity (75%). The in silico ADMET properties of 14c and 11a support
their drug-likeness.