Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score.
Minh-Phuong Huynh-LeRoshan KarunamuniChun-Chieh FanAsona J LuiWesley K ThompsonMaria Elena MartinezRosalind A EelesZsofia Kote-JaraiKenneth Ross MuirArtitaya LophatananonJohanna SchleutkerNora PashayanJyotsna BatraHenrik GronbergDavid E NealBørge Grønne NordestgaardCatherine M TangenRobert J MacInnisAlicja WolkDemetrius AlbanesChristopher A HaimanRuth C TravisWilliam J BlotJanet L StanfordLorelei A MucciCatharine M L WestSune F NielsenAdam S KibelOlivier CussenotSonja I BerndtStella KoutrosKarina Dalsgaard SørensenCezary CybulskiEli Marie GrindedalFlorence MenegauxJong Y ParkSue A InglesChristiane MaierRobert J HamiltonBarry S RosensteinYong-Jie LuStephen WatyaAna VegaManolis KogevinasFredrik WiklundKathryn L PenneyChad D HuffManuel R TeixeiraLuc MultignerRobin J LeachHermann BrennerEsther M JohnRadka KanevaChristopher J LogothetisSusan L NeuhausenKim De RuyckPiet OstAzad RazackLisa F NewcombJay H FowkeMarija GamulinAswin AbrahamFrank ClaessensJose Esteban CastelaoPaul A TownsendDana C CrawfordGyorgy PetrovicsRon H N van SchaikMarie-Elise ParentJennifer J HuQuan Longnull nullnull nullnull nullnull nullnull nullnull nullnull nullIan G MillsOle A AndreassenAnders M DaleTyler M SeibertPublished in: Prostate cancer and prostatic diseases (2022)
We demonstrate better genetic risk stratification for clinically significant prostate cancer than prior versions of PHS in multi-ancestry datasets. This is promising for implementing precision-medicine approaches to prostate cancer screening decisions in diverse populations.