Sex Differences in Amyotrophic Lateral Sclerosis Survival and Progression: A Multidimensional Analysis.
Maurizio GrassanoCristina MogliaFrancesca PalumboEmanuele KoumantakisPaolo CugnascoStefano CallegaroAntonio CanosaUmberto ManeraRosario VastaFilippo De MatteiEnrico MatteoniGiuseppe FudaPaolina SalamoneGiulia MarcheseFederico CasaleFabiola De MarchiLetizia MazziniGabriele MoraAndrea CalvoAdriano ChioPublished in: Annals of neurology (2024)
The shorter survival in men is linked to worse respiratory function and weight loss rather than a faster disease progression. These findings emphasize the importance of considering sex-specific factors in understanding ALS pathophysiology and designing tailored therapeutic strategies. ANN NEUROL 2024.