Prevention and treatment of fetal cytomegalovirus infection with cytomegalovirus hyperimmune globulin: a multicenter study in Madrid.
Daniel Blázquez-GameroAlberto Galindo IzquierdoTeresa Del RosalFernando Baquero-ArtigaoNuria Izquierdo MéndezMaría Soriano-RamosPablo Rojo ConejoMaría Isabel González-ToméAntonio García-BurguilloNoelia Pérez PérezVirginia SánchezJose Tomás Ramos-AmadorMaria De la CallePublished in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2017)
Prophylactic HIG administration in pregnant women after CMV primary infection seems not to reduce significantly the rate of congenital infection, but is safe and it could have a favorable effect on the symptoms and sequelae of infected fetuses. The risk of long-term sequelae in fetuses without US abnormalities before HIG is low, so it could be an option in infected fetuses with normal imaging. On the other hand, the risk of sequelae among infected fetuses with abnormalities in fetal ultrasonography before HIG despite treatment is high.