Integrating Network Pharmacology and Experimental Validation to Explore the Effects and Mechanisms of Qinghao Biejia Decoction and Its Active Compound Artemisinin B Against Non-Small-Cell Lung Cancer.

Yonghua YeYuping YangLi YanLi ZhouShihui YuQuan DuXiaoqiao DongQiang YuanLe-Tian ShanLe Guo

Published in: Drug design, development and therapy (2023)

This study revealed the anti-NSCLC efficacy of QBD. ART B, the effective component of QBD, plays an anti-NSCLC role by down-regulating the PI3K-Akt signaling pathway. It suggests that QBD and ART B are promising drug candidates for NSCLC treatment.

Keyphrases

small cell lung cancer
advanced non small cell lung cancer
signaling pathway
hiv infected
brain metastases
antiretroviral therapy
pi k akt
single cell
epithelial mesenchymal transition
induced apoptosis
adverse drug
replacement therapy
plasmodium falciparum
oxidative stress