Identification of Time-Series Pattern Marker in Its Application to Mortality Analysis of Pneumonia Patients in Intensive Care Unit.
Suhyeon LeeSuhyun KimGayoun KohHongryul AhnPublished in: Journal of personalized medicine (2024)
Electronic Health Records (EHRs) are a significant source of big data used to track health variables over time. The analysis of EHR data can uncover medical markers or risk factors, aiding in the diagnosis and monitoring of diseases. We introduce a novel method for identifying markers with various temporal trend patterns, including monotonic and fluctuating trends, using machine learning models such as Long Short-Term Memory (LSTM). By applying our method to pneumonia patients in the intensive care unit using the MIMIC-III dataset, we identified markers exhibiting both monotonic and fluctuating trends. Specifically, monotonic markers such as red cell distribution width, urea nitrogen, creatinine, calcium, morphine sulfate, bicarbonate, sodium, troponin T, albumin, and prothrombin time were more frequently observed in the mortality group compared to the recovery group throughout the 10-day period before discharge. Conversely, fluctuating trend markers such as dextrose in sterile water, polystyrene sulfonate, free calcium, and glucose were more frequently observed in the mortality group as the discharge date approached. Our study presents a method for detecting time-series pattern markers in EHR data that respond differently according to disease progression. These markers can contribute to monitoring disease progression and enable stage-specific treatment, thereby advancing precision medicine.
Keyphrases
- electronic health record
- big data
- risk factors
- end stage renal disease
- intensive care unit
- newly diagnosed
- healthcare
- chronic kidney disease
- cardiovascular events
- ejection fraction
- prognostic factors
- machine learning
- type diabetes
- blood pressure
- single cell
- metabolic syndrome
- cardiovascular disease
- adipose tissue
- mesenchymal stem cells
- skeletal muscle
- mechanical ventilation
- working memory
- data analysis
- uric acid