Estrogen-Related Receptors Gene Expression and Copy Number Alteration Association With the Clinicopathologic Characteristics of Breast Cancer.

Aymen Shatnawi Nehad M AyoubAmer E AlkhalifaDalia R Ibrahim

Published in: Breast cancer : basic and clinical research (2022)

In this clinical dataset, ESRRα and ESRRγ mRNA expression and CNA show a significant correlation and association with distinct clinicopathologic and prognostic parameters known to influence treatment outcomes; however, ESRRβ failed to show a robust role in BC pathogenesis. ESRRα and ESRRγ can be employed as therapeutic targets in BC-targeted therapy. However, the role of ESRRβ in BC pathogenesis remains unclear.

Keyphrases

copy number
gene expression
mitochondrial dna
dna methylation
genome wide
estrogen receptor