Extracellular vesicle miRNAs drive aberrant macrophage responses in NSAID-exacerbated respiratory disease.
Franziska HartungPascal HaimerlSonja SchindelaVeronika MussackBenedikt KirchnerFiona D R HenkelUlrike BernhardtUlrich M ZisslerRachel Santarella-MellwigMichael W PfafflCarsten B Schmidt-WeberAdam M ChakerJulia Esser-von BierenPublished in: Allergy (2024)
Aberrant airway EV miRNA profiles may contribute to immune dysfunction and chronic type 2 inflammation in N-ERD. Let-7 family miRNAs represent targets for correcting aberrant macrophage activation and mediator responses in N-ERD.