Hydroxychloroquine levels in patients with systemic lupus erythematosus: whole blood is preferable but serum levels also detect non-adherence.

Benoit BlanchetMoez JallouliMarie AllardPascale Ghillani-DalbinLionel GalicierOlivier AumaîtreFrançois ChassetVéronique Le GuernFrédéric LiotéAmar SmailNicolas LimalLaurent PerardHélène Desmurs-ClavelDu Le Thi HuongBouchra AsliJean-Emmanuel KahnLaurent SaillerFélix AckermannThomas PapoKarim SacréOlivier FainJérôme StirnemannPatrice CacoubGaelle LerouxJudith Cohen-BittanJérémie SellamXavier MarietteClaire GoulvestreJean Sébastien HulotZahir AmouraMichel VidalJean-Charles Piettenull nullNoémie Jourde-ChicheNathalie Costedoat-Chalumeau

Published in: Arthritis research & therapy (2020)

These data suggest that whole blood is better than serum for assessing the pharmacokinetic/pharmacodynamic relation of HCQ. Our results support the use of serum HCQ levels to assess non-adherence when whole blood is unavailable.

Keyphrases

electronic health record
type diabetes
metabolic syndrome
machine learning
adipose tissue
skeletal muscle
deep learning
data analysis