The N6-methyladenosine METTL3 regulates tumorigenesis and glycolysis by mediating m6A methylation of the tumor suppressor LATS1 in breast cancer.

Youqin XuMu SongZiyang HongWancheng ChenQianbing ZhangJianlong ZhouChao YangZilong HeJuanjuan YuXiaolin PengQiuhong ZhuShaotian LiKaiyuan JiMinfeng LiuQiang Zuo

Published in: Journal of experimental & clinical cancer research : CR (2023)

In summary, we discovered that the METTL3-LATS1-YTHDF2 pathway plays an important role in the progression of breast cancer by activating YAP/TAZ in the Hippo pathway.

Keyphrases

signaling pathway
dna methylation
gene expression