A covalent organic framework-based nanoreactor for enhanced photothermal therapy via inhibiting intracellular heat defense systems.

Yan-An LiJing-Jing WanWen-Yan LiQun Guan Yu-Bin Dong

Published in: Chemical communications (Cambridge, England) (2023)

Herein, we report an indocyanine green (ICG)-decorated and glucose oxidase (GOx)-loaded nanoscale composite COF material via a stepwise post-synthetic modification. The obtained GOx@COF-ICG can achieve synergistic inhibition of intracellular heat defense systems through starvation therapy to enhance photothermal therapy of tumors.

Keyphrases

fluorescence imaging
heat stress
cancer therapy
reactive oxygen species
drug delivery
signaling pathway
blood glucose
stem cells
quantum dots
type diabetes
wound healing
skeletal muscle
high resolution
weight loss