Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity.

Shivani Bansal Sunil BansalBrian L FishYaoxiang LiXiao XuJose A Fernandez John H Griffin Heather A Himburg Marjan BoermaMeetha MedhoraAmrita K Cheema

Published in: International journal of radiation biology (2023)

Taken together, these results show that augmenting the Protein C pathway and activity via administration of recombinant APC may be an effective approach for mitigation of radiation induced normal tissue toxicity.

Keyphrases

radiation induced
radiation therapy
oxidative stress
protein protein
climate change
amino acid
binding protein
small molecule
newly diagnosed