Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation.

Akos PalYasmin AsadRuth RuddleAlan T HenleyKaren SwalesShaun DecordovaSuzanne A EcclesIan CollinsMichelle D GarrettJohann De BonoUdai BanerjiFlorence I Raynaud

Published in: Metabolomics : Official journal of the Metabolomic Society (2020)

AT13148 affects metabolites associated with NOS in cells, mice and patients which is consistent with the clinical dose-limiting hypotension.

Keyphrases

end stage renal disease
induced apoptosis
ejection fraction
prognostic factors
cell cycle arrest
peritoneal dialysis
ms ms
patient reported outcomes
oxidative stress
adipose tissue
cell death
nitric oxide
signaling pathway
high fat diet induced