Unveiling the HER2-low phenomenon: exploring immunohistochemistry and gene expression to characterise HR-positive HER2-negative early breast cancer.

M GaudioF JacobsC BenvenutiG SaltalamacchiaR GerosaRita De SanctisA SantoroA Zambelli

Published in: Breast cancer research and treatment (2023)

Due to the substantial overlap, the HER2 gene expression is unable to properly distinguish HER2-low and HER2-zero IHC whose accurate identification is critical in the context of HER2-negative BC.

Keyphrases

gene expression
early breast cancer
dna methylation
high resolution
mass spectrometry