The Borono-Strecker Reaction: Synthesis of α-Aminoboronates via a Multicomponent Reaction of Carbonyl Compounds, Amines, and B2pin2.

We report the first Borono-Strecker reaction, a multicomponent reaction for the synthesis of α-aminoboronic acid derivatives from readily available carbonyl compounds, amines, and B2pin2. Diverse α-aminoboronates, including aryl-substituted and tertiary examples, were synthesized in moderate to high isolated yields. Compounds were prepared bearing N-(2-pyridyl) groups, which form five-membered rings via N-B coordination, as well as systems bearing noncoordinating N-aryl groups, the latter being isolated and fully characterized for the first time.